The UCI Lysosomal Storage Disorder Program is a team of specialized healthcare providers including doctors, nurses, and genetic counselors with experience diagnosing and treating these rare disorders.
There are more than 40 known lysosomal storage disorders. They are caused by a change in important genetic information in a person's DNA, or the instructions for the body.
This change in the DNA causes the body's to not be able to make a specific kind of protein, called an "enzyme". There are many types of enzymes. Each enzyme is responsible for breaking down, or digesting, a certain compound in the body. There are a group of enzymes that normally get rid of unwanted substances in the body. A lack of these enzymes leads to a lysosomal storage disorder.
When an enzyme is missing, the compound it should break down builds up in the body. This is because the body does not have a way to dispose of the compound without the enzyme. The body stores the compound in the lysosomes, small compartments in the body's cells. Lysosomes act as the "recycling center" of each cell, breaking down unwanted material into simple products for the cell to use to build new material. This is where the term "lysosomal storage disease" comes from.
As the lysosomes get more and more full, the cell can become damaged and unable to do its job. This progressive storage of materials in the lysosomes causes damage to cells and tissues, which leads to the symptoms of the disease. This abnormal storage causes the cells to not work as well as they should and leads to damage of the body's cells. This can cause serious health problems. This is why it is important to have a healthcare team familiar with the condition.
While all lysosomal storage disorders have different symptoms, all of the disorders are caused by the storage of a compound in the lysosome that the body is unable to break down.
Many of these disorders are rare, but some occur more often in people of certain ethnic groups. Because these disorders can be passed down through families, or inherited, in different patterns, a person's risk of passing this condition on to his or her children depends on the disease and the individual's family background. Genetics professionals can help answer questions about this area.
Virginia Kimonis, MD
Geneticist
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John Jay Gargus, MD, PHD
Geneticist
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Marie Wencel
Clinical Research Coordinator
Annabel Wang, MD
Neurology / Neuromusclar disorders
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Tasheen Mozaffar, MBBS
Neurology / Neuromusclar disorders
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Patricia Tully, Nurse Practicioner
Neurology / Neuromuscular disorders
Pulmonologists
Cardiologists
Due to the complexity of lysosomal storage disorders, it is important for patients and their families to be followed by a team of healthcare providers and medical experts who are familiar with the conditions. Our specialized team of experts offers comprehensive services including:
We are involved with a study that is evaluating a therapy for a storage disorder described as LysosomalAcid Lipase (LAL) Deficiency.
This condition may present at any age, but an early onset (WolmanDisease) form has a particularly severe presentation and outcome. Lysosomal Acid Lipase (LAL) Deficiency is a rare genetic disease with significant morbidity and earlymortality. Specifically, LAL Deficiency is an autosomal recessive lysosomal storage disorder that resultsin marked decrease in the activity of the enzyme lysosomal acid lipase, which leads to lipid (cholesterylesters and triglycerides) accumulation in various tissues and cell types.
The early onset form of LAL Deficiency has a reported incidence of 2 births per million in a general population, although it could be as high as 238 per million in certain groups such as Persian Jewish population of Los Angeles. Most babies born with the early onset form of LAL Deficiency (Wolman Disease) appear healthy at birth and typically present before 3 months of age with persistent vomiting, diarrhea, abdominal distension,and failure to thrive. However, the disease is rapidly progressive and has nearly 100% mortality in the first year of life.
UC Irvine and Synageva BioPharma are conducting a clinical trial investigating an enzyme replacement therapy for early onset LALDeficiency. Please see the link to www.clinicaltrials.gov below:
Wolman Family Support Group:
University of California, Irvine Medical Center
Lysosomal Storage Disorder Program
101 The City Drive Ste 800
Orange, CA 92868
Phone: 714-456-5792
Fax 714-456-5330
Sponsored by an education grant from Genzyme Corporation
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